1, age ≥ 65 years; 2, hypertension; 3, diabetes; 4, hyperlipidemia; 5, atrial fibrillation; 6, obese; 7, smokers; 8, alcoholism; 9, history of coronary heart disease; 10, hyperhomocysteinemia; 11, lack of physical exercise in mental labor; 12, family history of cardiovascular disease; 13, history of peripheral arterial disease; 14, who have had a stroke or TIA.