Compared with gastroscopy and biopsy, biopsy is more accurate and has a definite diagnostic significance. Gastroscopy can directly observe the examined area and find abnormal gastric mucosal lesions, such as gastric mucosal congestion, edema, ulcers and swelling. The type of disease is determined by the doctor’s experience, but there is a certain error, and there is the possibility of leakage and misdiagnosis. Biopsy refers to the microscopic observation of the subtle changes in the diseased tissue, which has the significance of confirming the diagnosis. If inflammatory cell infiltration, intestinal epithelial hyperplasia, atypical hyperplasia and other pathological changes are found, the type of lesion can be clarified. If the abnormal tissue is not taken under gastroscopy, it can also cause missed diagnosis and misdiagnosis. For the diagnosis of gastric diseases, it is recommended to be judged by the doctor in conjunction with gastroscopy and pathological biopsy, symptoms and so on.