Knee cartilage regeneration literally refers to the phenomenon of cartilage recovery through regeneration after damage has occurred; however, articular cartilage generally cannot regenerate on its own. Knee cartilage is damaged to varying degrees by localized inflammation or long-term wear and tear. If the articular cartilage can regenerate and develop normally, the cartilage can be restored to its normal state, thus ensuring a healthy joint structure and joint movement. However, since bone cells and chondrocytes do not have the ability to differentiate and regenerate, articular cartilage cannot regenerate on its own. Previous studies have reported that cartilage regeneration generally requires the use of stem cells and other primitive cells to effectively promote cell differentiation and proliferation, which can help to achieve the effect of cartilage regeneration. However, there is no standardized treatment requirement for articular cartilage regeneration, so it is difficult to regenerate articular cartilage. If there is cartilage damage in the knee joint, it is recommended to go to the hospital for an X-ray examination and consult the doctor’s advice.