Prednisone is prednisone, methylprednisolone and prednisone can not be directly judged which side effects, the two common types of side effects are similar, but due to the patient’s personal constitution, specific conditions and the dose of the drug, etc. show different degrees of adverse reactions. Prednisone and methylprednisolone both belong to the medium-acting glucocorticoid drugs, prednisone and methylprednisolone drug side effects are similar, taking prednisone and methylprednisolone drugs may appear class Cushing state, opportunistic infections, osteoporosis, glucose tolerance abnormalities, hypertension, gastrointestinal ulcers, and other side effects of drugs. However, methylprednisolone causes less liver damage and water and sodium retention than prednisone. In addition, the severity of adverse reactions after taking prednisone or methylprednisolone may vary depending on age, gender, weight, underlying disease, physical strength, duration of use, and drug dosage. Therefore, Prednisone or Methylprednisolone should be taken under the supervision of a physician and in accordance with medical advice. It is recommended that patients who need to take prednisone or methylprednisolone go to the relevant departments of regular hospitals for detailed counseling, do not take the drug on their own.