Saline water is not at all effective in relieving toothache. There are several possibilities for toothache, usually due to pulpitis or periapical inflammation caused by tooth decay, and also due to soft tissue inflammation around the wisdom teeth caused by wisdom teeth obstruction, that is, wisdom teeth pericoronitis. The best way to relieve toothache is to visit a hospital to determine the cause and treat the problem. In the case of pulpitis or periapical inflammation, systematic root canal treatment should be performed on the affected tooth. Effective root canal treatment can completely relieve toothache, remove inflammation in the root canal and periapical tissues, and permanently fill the tooth to isolate external stimuli and prevent reinfection. If the toothache is caused by periapical inflammation of the wisdom tooth, anti-inflammatory symptomatic treatment should be carried out in the acute stage, either oral anti-inflammatory drugs or infusion, and the soft tissues and blind pockets around the wisdom tooth should be rinsed with hydrogen peroxide and saline alternately locally to remove local stimulation, and the pain can be gradually relieved and the inflammation gradually disappears in 1-2 weeks, and the wisdom tooth should be extracted under local anesthesia to eliminate future problems.