Elderly people over 70 years of age need to take aspirin for a long period of time if they have clearly got cardiovascular disease; if they do not have cardiovascular disease, it is not recommended to take aspirin for prevention. Aspirin is currently mainly used in the secondary prevention of coronary atherosclerotic cardiovascular disease and its part of the primary prevention of high-risk patients, when the elderly use aspirin for primary prevention there are age limitations. For elderly individuals who have been clinically diagnosed with cardiovascular and cerebrovascular diseases and need to take aspirin for a long period of time, they need to go to the hospital regularly to monitor the INR (international standardized prothrombin time), and then adjust the medication according to the changes in its value as prescribed by the doctor. For older individuals without cardiovascular disease, if there are high risk factors for the development of the disease, such as smoking, high blood cholesterol, etc., and the age of > 70 years is not recommended to take aspirin for primary prevention, must take aspirin for primary prevention of individuals, need to refer to the guidelines after the scoring, and comply with the doctor’s instructions to decide whether to use. Aspirin can cause gastrointestinal discomfort and, rarely, transient liver damage; it is contraindicated in individuals who are allergic to aspirin or other salicylates, have perforated peptic ulcers, or have severe hepatic or renal dysfunction. In summary, the use of aspirin in older adults >70 years of age depends on the situation, for individuals with definite cardiovascular disease, regardless of age, the use of aspirin secondary prevention is required, and if the use of primary prevention, individuals >70 years of age is not recommended. For specific cases, it is recommended to seek medical attention in a timely manner and follow the doctor’s instructions for the relevant consultation.