Earlobe crease does not necessarily mean coronary heart disease, earlobe crease is common in obese people and the elderly, genetic factors can also lead to earlobe crease. For obese patients and elderly patients, the accumulation of risk factors often leads to a high incidence of coronary heart disease, but does not necessarily mean that the earlobe folds occur in coronary heart disease. Genetic causes of earlobe creases are not associated with coronary artery disease. The diagnosis of coronary artery disease is based on the patient’s medical history, symptoms, signs and symptoms, combined with laboratory and imaging tests. Coronary artery disease consists of many types, and elevated markers of myocardial damage can help to classify and treat patients with coronary artery disease.