Side effects of progesterone include spot vaginal bleeding, acne, seborrhea, fluid retention, weight gain, hirsutism, voice changes, hair loss and other androgenic effects. Other adverse effects are transient elevation of aminotransferases, headache, gastrointestinal disturbances, change in libido, hot flashes, breast size reduction, nervousness and depression, abdominal pain, appetite changes, and arthralgia. Not everyone will exhibit side effects, they vary from person to person and the degree of side effects varies. Progesterone is a prescription drug, patients should be strictly contraceptive while taking the drug, regular checks on liver function, patients with high blood lipids, diabetic patients need regular monitoring. When patients are taking progesterone, it is recommended that it be used under the guidance of a doctor, and if any discomfort occurs, it is recommended that they seek medical attention in a timely manner, so that a professional doctor can make a diagnosis and decide whether or not to continue taking the medication.