About whether mothers with hepatitis B can breastfeed and how to prevent their children from being infected, has been a matter of great concern, some parents consult multiple doctors and get different answers, bringing many doubts to everyone, the following is the guidance in the national guidelines on the prevention and treatment of hepatitis B, which is also the most formal method: For newborns of HbsAg-positive mothers, they should be injected within 24 hours after birth Hepatitis B immunoglobulin should be injected as early as possible, preferably within 12 hours, at a dose greater than 100 IU, along with 10ug of recombinant yeast hepatitis B vaccine at different sites. Alternatively, 1 dose of immunoglobulin can be given within 12 hours of birth, followed by a second dose of immunoglobulin 1 month later, along with 10ug of recombinant yeast hepatitis B vaccine at a different site. The second and third doses of hepatitis B vaccine (10 ug of recombinant yeast hepatitis B vaccine each) are given 1 and 6 months apart. The latter is less convenient than the former, but its protection rate is higher than that of the former. Newborns can be breastfed by HbsAg-positive mothers after hepatitis B immunoglobulin and hepatitis B vaccine are administered within 12 hours of birth.