There is a difference between metformin hydrochloride tablets and extended-release tablets. The difference between metformin hydrochloride tablets and extended-release tablets is mainly in the rate of release of the drug, with metformin extended-release tablets releasing more slowly. Follow your doctor’s instructions for specific medications. Extended-release tablets of metformin hydrochloride than tablets, the difference is that the appearance of the drug is added to the advanced process, after taking the drug can slowly release the contents, making the effect of lowering sugar more smoothly. Both Metformin Hydrochloride Tablets and Extended-Release Tablets improve and control blood glucose and are suitable for use in reducing fasting and postprandial hyperglycemia in patients with type 2 diabetes, among other conditions. Adverse drug reactions include nausea, vomiting, diarrhea, abdominal pain, and constipation. The other two drugs should be contraindicated in type 2 diabetes mellitus with ketoacidosis, severe infection and trauma, major surgery and other conditions, diabetes combined with severe chronic complications, alcoholics, vitamin B12 or folic acid or iron deficiency. Specific medication should be administered under the guidance of a specialist, and should not be used without authorization.