Hypoechoic area in the head of the pancreas with unclear borders and no blood flow signal usually refers to the ultrasound scanning of the pancreas, which reveals a hypoechoic area in the head of the pancreas with unclear borders and no blood flow signal, which may suggest inflammation of the pancreas, pancreatic cysts, or space-occupying lesions. Hypoechoic areas with poorly defined borders and no blood flow signal may be due to inflammatory lesions, pancreatic cysts, or space-occupying lesions. It is necessary to combine the size of the echo-less area and clinical symptoms to make a comprehensive judgment. Ultrasound examination of the pancreas is affected by the abdominal organs and gas, and it is recommended to further combine with the enhanced CT of the pancreas and CA199, a tumor marker for pancreatic cancer, in order to make a clear diagnosis. It is recommended to interpret the results in combination with the clinician’s opinion and treat under the doctor’s guidance to avoid delay.