24-hour urine protein measurement is more commonly used in clinical practice. Under normal circumstances, urine does not contain protein, and when urine protein appears positive, such as (+)-(++++), further 24-hour urine protein quantification is recommended, and urine density multiplied by volume is equal to 24-hour urine protein quantification. If the urine protein quantification is greater than 3.5g/24h it indicates massive proteinuria, which is most commonly seen in clinical practice in nephrotic syndrome and diabetic nephropathy. If the 24-hour urine protein quantification is between 1-3.5g, it is a moderate amount of proteinuria, which is most common in hypertensive kidney damage, glomerulonephritis, vasculitis kidney damage, etc. If the 24-hour urine protein is only mild, such as less than 1g, consider some mild kidney damage, such as early diabetic nephropathy, active urine protein-lowering treatment is recommended, the most commonly used urine protein-lowering drugs are ACEI and ARB class, such as valsartan and benazepril.