B-cell lymphoma is a relatively common lymphoma that can be cured by considering the application of chemotherapy combined with targeted drug therapy. If there is no recurrence for more than 5 years, it is considered to be clinically cured. Of course, there is still a possibility of recurrence after 5 years, but the chance of recurrence will be much lower. Lymphoma is a systemic disease, a malignant tumor of the hematopoietic system, characterized by painless progressive lymph node enlargement with or without hypothermia, night sweats, and weakness, and can be diagnosed by pathological biopsy of lymph nodes. Some lymph nodes that do not grow on the surface of the body but exist in the mediastinum and abdominal cavity can be diagnosed by puncture biopsy or ascites test, after the diagnosis is confirmed, combined treatment is needed, and early detection and treatment is more effective.