MALT lymphoma, a lymphoma of the marginal zone of extrajunctional mucosa-associated lymphoid tissue, can be further divided into gastric MALT and non-gastric MALT lymphoma. the clinical manifestations of MALT lymphoma are mainly diverse depending on the site of occurrence. Overall, it develops slowly and is an inert lymphoma. The disease rarely metastasizes to distant sites, and most people are usually in stage I or II when diagnosed. The gastrointestinal tract is the most commonly involved site of MALT lymphoma, accounting for approximately 50% or more of cases. The stomach is involved in 85% of cases, which manifests as abdominal pain, anemia, bloating, black stools, weight loss, nausea, and vomiting. In addition, abdominal masses or enlarged lymph nodes are generally less common. Other non-gastric MALT lymphomas can involve the bone marrow, lung, head and neck, eye appendages, as well as the skin, thyroid, and breast, etc. Symptoms related to the site of involvement are mostly seen, and systemic symptoms are generally less common.