Nighttime scrotal itching may be caused by scrotal eczema, pubic lice disease or scabies. 1. Eczema: when eczema occurs in the scrotum, anus, localized intense itching, can be due to excessive scratching local redness, swelling, oozing, long-term recurrent episodes become chronic, the skin has mossy changes. 2. Pubic lice disease: can be caused by unclean sexual contact history, can cause itching of pubic hair area, worse at night, in the pubic hair can be attached to the pubic lice and gray-white granular material that is lice eggs, pubic lice can be slow to move, the scrotum can also be itchy. 3. Scabies: when the scabies mite invades the scrotum, finger cracks and other thin and tender parts of the skin or buttocks, etc., it can cause the skin to appear pimples, pimples, scabies nodules occur in the scrotum, with intense itching, especially at night. Frequent itching of the scrotum, it is recommended to consult a doctor in time, and follow the doctor’s instructions for targeted treatment.