Adrenocortical hyperplasia is hereditary and is caused by an enzyme defect in hormone synthesis, resulting in abnormal corticosteroid synthesis. Relevant studies have shown that adrenocortical hyperplasia can be inherited through autosomal recessive inheritance, so the occurrence of this disease is related to heredity. In addition, the adrenal glands synthesize three main types of hormones from cholesterol, namely glucocorticoids, salocorticoids, and sex hormones, such as androgens, estrogens, and progesterones. Therefore, when there are enzyme defects in different parts of the process of hormone synthesis leading to a decrease in the cortisol level of the above three types of hormones, the negative feedback effect is eliminated, resulting in an increase in the secretion of ACTH from the anterior pituitary gland, which causes stimulation of the adrenal cortex and then overgrowth, causing hyperplasia, which leads to hyperplasia of the adrenal cortex. Common symptoms include pseudohermaphroditism in girls and pseudo precocious puberty in boys. When adrenocortical hyperplasia is detected, it is necessary to go to the hospital in time and cooperate with the doctor for active treatment.