Severe aplastic anemia fever can be treated with physical cooling, medication (ibuprofen or acetaminophen), anti-infective treatment and etiology. 1. Physical hypothermia: can be done by loosening clothing, cold compresses or alcohol scrubbing of the armpits and popliteal fossa. 2. Medication: oral ibuprofen or acetaminophen. 3. Anti-infection treatment: fever of reoccurrence is mostly caused by infection, mainly respiratory tract infection, sputum culture + drug sensitivity test can be carried out. Drugs include levofloxacin. 4. Etiological treatment: In addition to the above treatment, etiological treatment is very important, such as oral cyclosporine, etc., in order to treat aplastic anemia from the root. Severe aplastic anemia when there is a fever, to reduce cold, spicy and other food stimulation, the first time to the hospital, so as not to develop into bacteremia and other life-threatening. Specific treatment should be carried out under the guidance of physicians.