Unilateral numbness of the tips of the fingers may be caused by physiological factors such as prolonged compression of the arm, or it may be caused by cervical spondylosis, diabetes mellitus, carpal tunnel syndrome and other causes. 1. Physiological factors: if the arm is compressed for a long time, or localized cold, there may be unilateral numbness of the fingertips. 2. Cervical spondylosis: severe cervical spondylosis can make the brachial plexus nerve compression, there will also be unilateral numbness of the fingers. The numbness is usually severe after exertion and relieved after rest. 3. Diabetes mellitus: when severe hyperglycemia causes diabetic peripheral neuropathy, there will be numbness in the tip of the fingers, and it will be gradually aggravated. 4. Carpal tunnel syndrome: patients with carpal tunnel syndrome can cause damage to the median nerve, there will be numbness on the affected side of the fingers, and aggravated by the activities of the wrist joint. Unilateral numbness of the tip of the fingers in the exclusion of physiological conditions, should go to the regular hospital as soon as possible, in the professional doctor’s help for diagnosis and treatment.