Causes of skin blisters include papular urticaria, herpes zoster, herpes sweat, pemphigus or herpetic pemphigoid. 1. papular urticaria: the disease can appear in the local skin of the red wind-bubble-like papules, the center can be seen blisters, accompanied by obvious itching sensation. 2. Herpes zoster or herpes simplex: mainly caused by viral infections, mainly manifested as banded or aggregated distribution of blisters, this situation can be applied locally acyclovir cream or oral acyclovir tablets for antiviral treatment, and in severe cases can be injected intravenously. 3. Sweat blisters: more frequent in summer, increased sweating in summer, the skin for a long time in a humid environment leading to localized blisters, and accompanied by different degrees of burning and itching. 4. Pemphigus or herpetic pemphigoid: all belong to autoimmune skin diseases, blisters can appear in the oral mucosa, trunk, limbs and other parts of the body, can be diagnosed by histopathology and immunofluorescence examination. Glucocorticoids such as prednisone or methylprednisolone are given for treatment. If the skin blisters should be timely to the regular hospital, after a clear diagnosis of symptomatic treatment, drugs need to be used in accordance with the doctor’s instructions, do not blindly deal with their own.