Stomach pain with normal Helicobacter pylori test is mostly considered as acute gastroenteritis, chronic gastritis, peptic ulcer, gastric cancer and other diseases, which can be relieved by general treatment, medication and surgery. 1. General treatment: When patients have stomach pain, they can have gentle massage or hot compress on the stomach to relieve the pain. Usually should pay attention to diet, avoid eating cold and spicy foods that stimulate the gastric mucosa, and barbecue and other indigestible foods, quit smoking and drinking. At the same time, pay attention to avoid staying up late, develop good eating habits, avoid overeating. 2. Medication: If the patient’s stomach pain is caused by acute gastroenteritis due to unclean diet, he can take gentamicin, cephalosporin, quinolones and other antibiotics for anti-infective treatment; if it is due to chronic gastritis, peptic ulcer and other diseases, he can take omeprazole, bismuth potassium citrate and other acid-suppressing medicines or medicines to protect the gastric mucosa. 3. Surgical treatment: If the patient is caused by gastric polyps, gastric cancer and other diseases, surgical treatment can be considered. For patients with stomach pain but normal H. pylori test, it is recommended to consult a doctor in time and receive treatment actively. The medication should be taken in strict accordance with the doctor’s instructions, and should not be used on its own, so as not to delay or even aggravate the condition.