Cholestasis of the gallbladder is mainly due to poor drainage of bile or infection in the gallbladder. The specific treatment options are removal of the cause, symptomatic supportive therapy, and liver transplantation. Patients need to be actively treated under the guidance of a physician.1. Remove the cause: For gallbladder cholestasis with a clear cause, the cause needs to be removed to control the disease. If gallbladder bile sludge is caused by stenosis of the cystic duct, stenosis of the lower common bile duct, bile duct stricture, bile duct stone obstruction, bile duct tumor obstruction, etc., antispasmodic and symptomatic treatment is needed for benign diseases, and if drug treatment is ineffective, patency drainage needs to be given. If gallbladder bile sludge is caused by gallbladder infection, anti-inflammatory, antispasmodic and biliary treatment should be given for inflammation. Common drugs include ursodeoxycholic acid and cephalosporin antibiotics, which are helpful to promote the discharge of bile sludge in the gallbladder. 2. The commonly used drugs in clinical practice are ursodeoxycholic acid and adenosylmethionine. If cholestasis causes recurrent attacks of cholecystitis, the gallbladder can be removed to achieve radical cure if drug treatment is ineffective; 3, liver transplantation: end-stage gallbladder cholestasis diseases, such as congenital biliary atresia, sclerosing cholangitis, secondary biliary cirrhosis, intrahepatic bile duct atresia, etc., can be treated by liver transplantation.