Diffuse Abnormal Signal in the Liver Considering Iron Deposition is a condition in which a patient presents with a lesion in the liver tissue on imaging and is considered to have possible iron deposition, i.e., hemochromatosis. At this point, the patient will need further tests such as liver and biliary ultrasound and CT for diagnosis. If the patient is diagnosed with iron deposition, i.e. hemochromatosis. Hemochromatosis of the liver is mainly caused by excessive iron deposition on liver cells, leading to stromal cell destruction and fibrous tissue proliferation, which can manifest as skin pigmentation, secondary diabetes, and other symptoms. The treatment of hepatic hemochromatosis is mainly to remove the accumulated iron. If the patient has concomitant diabetes mellitus, insulin and oral hypoglycemic drugs such as metformin can be applied; if there is arthropathy, drugs such as ibuprofen and diclofenac diethylamide can be used for pain relief. In addition, patients with diffuse abnormal signal in the liver to consider iron deposition, further examination of liver and gallbladder ultrasound, CT, magnetic resonance and other diagnostic, and follow the doctor’s instructions for treatment.