There are many clinical drugs to reduce glutathione, but different drugs are used in different ways to achieve the effect of reducing glutathione, mainly divided into the following categories: I. Hepatoprotective agents. The common clinical use of polyenyl phosphatidylcholine, for steatohepatitis has a better effect. Second, detoxification and hepatoprotective drugs. Clinically, the commonly used drugs include reduced glutathione, thiopronine, glucuronide, etc., which have better effect on toxic hepatitis and drug hepatitis. Third, anti-inflammatory and hepatoprotective drugs. Mainly glycyrrhizin preparations, commonly used in clinical practice are compound glycyrrhizin monoammonium, compound glycyrrhizin diammonium, compound glycyrrhizin, etc. It has good effect on viral hepatitis, autoimmune hepatitis and severe hepatitis. In addition, there are some oral preparations that can also achieve better enzyme-lowering effect in clinical practice, such as bifenthrin, dicyclomine tablets, sunflower liver protection tablets, etc. However, it should be noted that lowering transaminases is not the main purpose, first of all, we should find the cause of the increase in transaminases, and deal with the cause, for example, if patients with hepatitis B have elevated transaminases, it is likely that the virus is reactive, and antiviral treatment should be given in time to better reduce transaminases.