The five major first-line antihypertensive drugs, including calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, diuretics and beta-blockers, are all useful in reducing systolic blood pressure. In the clinical selection of antihypertensive drugs, according to the patient’s specific clinical situation, reasonable selection, antihypertensive treatment should be individualized. Usually, patients with elevated systolic blood pressure are mostly seen in the elderly, and the main emphasis of antihypertensive treatment for the elderly is to achieve the systolic blood pressure standard. In the process of lowering blood pressure, we should avoid excessive lowering of blood pressure, and gradually lower the blood pressure to the target range as the patient can tolerate, and avoid lowering the blood pressure too fast and too low to avoid adverse consequences.