Inguinal lymph node swelling caused by swelling of the lower limbs, according to the causes of lymph node swelling need to be targeted treatment. 1. Infectious diseases: when pathogens infect patients, resulting in inguinal lymph node enlargement, compression of the veins leading to venous return obstruction, the patient’s lower limbs will appear swollen. At this time, we need to consult a doctor in time, to be cefixime, amoxicillin and other antibiotic drugs for treatment. When the lymph node inflammation subsides, the lymph nodes can be restored to their original size, lifting the pressure on the veins, thus eliminating edema. 2. Occupational disease: some patients have enlarged retro-abdominal lymph nodes, resulting in swelling of the lower limbs, caused by malignant tumors, at this time the patient needs to be based on the severity of the disease, under the guidance of the doctor to choose radiotherapy (paclitaxel, cisplatin, etc.) or surgical clean-up treatment. It is recommended that the patient consult a doctor in time to determine the cause of inguinal lymph node enlargement, thus causing swelling of the lower limbs, and targeted treatment.