Simethicone can be taken before or after meals, however, there are several precautions: 1. Simethicone is recommended to be taken with 50ml of lukewarm water, always remember to stir it with 50ml of lukewarm water and dissolve it. 2. If Simethicone is used at the same time with antibiotics or other drugs, such as amoxicillin capsules, levofloxacin tablets and other types of antibiotics, an interval of 2-3 hours is required, because Simethicone is a kind of adsorption medication, which can easily adsorb these drugs and thus affect the absorption. Therefore, if taken with other medications, an interval of 2-3 hours is recommended to prevent adsorption of the medications, which may affect their absorption. In addition, Simethicone is used to stop diarrhea. If the symptoms are relieved and the diarrhea stops, the drug needs to be stopped immediately to prevent constipation caused by prolonged use of the drug. Another typical therapeutic effect of Simethicone is that if you suffer from mouth ulcers, you can mix it with a small amount of warm water and put it on the ulcers, which can play a certain therapeutic role.