The main reason for the stomach pain after taking misoprostol is that misoprostol causes contraction of the smooth muscle of the uterus. Only the contraction of the smooth muscle of the uterus occurs to allow the elimination of the gestational sac from the uterine cavity, so this is the effect of misoprostol after taking it. The vast majority of this pain can be tolerated and the pain is usually relieved in ten minutes. It is advisable to rest in bed and to observe your vaginal bleeding in case of clinical abdominal pain. In the vast majority of cases, the vagina will expel the pregnancy product within about 2-6 hours after taking misoprostol. If there is an increase in vaginal bleeding while waiting for the pregnancy products to be expelled, more than the menstrual flow, it may be necessary to have the uterus removed clinically.