Taking entecavir can make the hepatitis B virus DNA turn negative, and only rarely make the surface antigen turn negative. Entecavir can inhibit the reproduction and replication of the virus in the body, after systematic treatment, it can make hepatitis B virus DNA quantitatively negative, but it can’t directly make the surface antigen of hepatitis B become negative, some people can achieve the effect of surface antigen becoming negative through long-term treatment or combined treatment with interferon. Hepatitis B virus DNA negative indicates that the virus is no longer replicating, clinical symptoms will be relieved, but still in the state of viral carriage, only when the surface antigen is negative, can achieve clinical cure. Hepatitis treatment takes time, mainly oral antiviral drugs, regular review of liver function, hepatitis B virus DNA and so on. Entecavir is mainly used for hepatitis patients with active viral replication and active lesions; it is forbidden to use it if there is allergy to its components; headache, fatigue, dizziness, nausea and other adverse reactions may occur after use. Hepatitis B patients need to consult a doctor in time and use the drug under the guidance of the doctor.