The difference between palmoplantar pustulosis and tinea cruris (scientific name “tinea cruris”) includes etiology, site of occurrence, main manifestations, prognosis and so on. 1. Different etiology: the cause of palmoplantar pustulosis is unknown, and may be related to infection, allergy, stress, smoking, etc. Tinea cruris is usually due to fungal infection, and the common fungi that cause infection include Trichophyton rubrum and Trichophyton rubrum. 2. Happening parts: palmoplantar pustulosis usually occurs in the palm of the hand, the palm of the foot surface, mostly symmetrical distribution; while tinea cruris will appear in the fingers, finger cracks and palm surface, often unilateral onset. 3. Main manifestations: palmoplantar pustulosis clinical manifestations mainly in the palm of the hand, the palm of the foot scattered distribution of small sterile pustules, pustules subside around the erythema, desquamation, etc.; and tinea cruris usually appear blisters, erythema, desquamation, hyperkeratosis, etc. lesions, but generally do not appear pustules. 4. Prognosis: palmoplantar pustulosis is a chronic disease, the condition is prolonged, can recur, seriously affecting the quality of life; while tinea cruris after regular antifungal treatment, and pay attention to the prevention of fungal infections, usually will not recur. Whether it is palmoplantar pustulosis or tinea cruris, it is recommended that patients with suspected symptoms go to the hospital in a timely manner to get a clear diagnosis and standardized treatment under the guidance of the doctor, so as to avoid delaying the condition.