If the number of Escherichia coli colonies in urine culture is ≥10^5/ml with increased leukocytes and epithelial cells, it is suggestive of a urinary tract infection and requires treatment. Only a small amount of bacteria exist in normal human urine, when gram-negative bacilli ≥10^5/L, the diagnosis is valuable, Escherichia coli belongs to a kind of conditional pathogenic bacteria, a large number of appear in the urinary system can cause urinary tract infection, resulting in urinary tract irritation symptoms such as urinary frequency, urinary urgency, urinary pain and other symptoms, need to be actively treated. When Escherichia coli infects the urinary tract, the main application of antibiotics for treatment, you can use furotoxin, levofloxacin and other antibiotics for treatment, if there is no effect, according to the drug sensitivity test to choose sensitive drugs for treatment. When the diagnosis of urinary tract infection is confirmed, it is necessary to choose the appropriate drugs for treatment under the guidance of the doctor.