The so-called high-risk Down screening results are usually when a woman is at about 16 weeks of pregnancy and about 12 weeks of pregnancy, when she has early and mid-term Down screening, and her test results are high-risk for Down screening. In this case, you should go to the obstetrics department of the hospital to have a special non-invasive DNA or amniocentesis test to determine if the fetus has trisomy 21. Since the results of both Down screening are high risk, it means that the chance of the fetus having Down syndrome is particularly high, so further determination should be made to confirm the diagnosis. If necessary, amniocentesis can be performed directly, as it has the highest accuracy rate. However, there are certain risks associated with amniocentesis, which may lead to intrauterine infection and miscarriage. For pregnant women with amniocentesis results that are trisomy 21, abortion should be induced to terminate the pregnancy.