Whether or not a blister on the mouth can be poked depends largely on the size of the blister on the patient’s mouth and what triggered the formation of the blister. If the blisters in the area are large and have high tension, they can be poked. However, care should be taken to disinfect the local lesion after puncturing, otherwise it may induce a corresponding infection, such as the formation of a bacterial infection. You can apply topical iodophor or topical antibiotic products, such as fusidic acid cream, after the puncture. However, if the blisters on the mouth are caused by a certain viral infection and the individual blisters are not large, you can apply topical acyclovir ointment directly, etc. If the blisters continue to grow and are relatively large, they can also be poked with a sterile needle as appropriate.