Most of the frequent farting after taking H. pylori quadruple drugs is caused by dysbiosis of the intestinal flora and over-suppression of gastric acid secretion. Intestinal flora dysbiosis is due to the fact that gastric acid can inhibit the reproduction of bacteria in the intestinal tract, while proton pump inhibitors such as omeprazole, pantoprazole, rabeprazole, etc. in the H. pylori quadruple combination of drugs can weaken the inhibitory effect of gastric acid, leading to overpopulation of anaerobic bacteria in the intestinal tract. Overpopulated intestinal anaerobic bacteria can break down undigested food, ferment, and produce gas, leading to frequent farting. Excessive suppression of gastric acid production has been linked to the use of proton pump inhibitors. Proton pump inhibitors have a potent and long-lasting gastric acid secretion blocking effect, which can lead to an increase in intragastric pH, thus affecting the activation of pepsinogen, which in turn affects protein hydrolysis. The intestinal anaerobic bacteria can break down these incompletely digested proteins, carry out fermentation and gas production, thus leading to frequent farting. It is recommended to pay attention to diet in daily life, and take digestive enzyme preparations and probiotics to regulate the intestinal flora under the guidance of a doctor for standardized treatment if necessary.