There are some differences between nifedipine and amlodipine benzenesulfonate in terms of duration of efficacy, pharmacologic mechanism, and adverse reactions and contraindications. 1. Amlodipine benzenesulfonate is a long-acting calcium antagonist and can be taken once a day. It mainly dilates peripheral blood vessels and also relieves angina pectoris, but the mechanism is still unclear. This product is mainly used in the treatment of hypertension, chronic stable angina, variant angina and other diseases. Common adverse reactions include edema, dizziness, palpitation, flushing, etc. It is prohibited for those who are allergic to amlodipine. 2. Nifedipine is a short-acting calcium antagonist, which is usually taken twice a day and has the effect of dilating peripheral blood vessels and coronary arteries. Nifedipine is mainly used for various types of hypertension and angina pectoris, and its adverse reactions include nausea, abdominal pain, constipation, headache, palpitation, etc. It is prohibited for those who are allergic to it, pregnant women and children. Please select the appropriate medication according to your condition under the guidance of your physician, and should not use the medication blindly to avoid delaying your condition.