The instructions of Huangkui capsule does not explicitly mention that patients with kidney disease need to use the drug with caution, and the drug is aimed at chronic nephritis in kidney disease. Clinical application should be based on the patient’s syndrome to identify the use of drugs. Huangkui Capsule is a kind of Chinese patent medicine, which has the effect of clearing dampness and heat, detoxifying and eliminating swelling, and is suitable for the treatment of chronic nephritis with symptoms of dampness and heat accompanied by lumbar pain, swelling, proteinuria, hematuria, and yellowish and greasy tongue coating. Therefore, patients with kidney disease can apply this medicine for treatment. However, Huangkui Capsules should be prohibited for pregnant women. Individual patients experienced adverse reactions such as distension and discomfort in the upper abdomen after using the medicine. It is recommended to use the medicine under the guidance of doctors, not blindly self-medication to avoid adverse effects. Patients with kidney disease are advised to go to the regular hospital in time, under the guidance of the doctor to standardize the treatment, do not self-medication.