Four stages in the natural course of liver cancer

  Liver cancer is a tumor with a very high degree of malignancy. China is a region with a high incidence of liver cancer, and the incidence rate has been slowly increasing in recent years, and the death rate has also increased, with about 200,000 patients dying of advanced liver cancer each year. The high incidence rate is also related to the fact that there are many hepatitis patients in China, and 85% of liver cancer patients are caused by viral hepatitis.  The onset of liver cancer is often insidious, and it is mostly discovered by chance during the follow-up of liver disease or physical examination and screening with AFP and B-type ultrasound. At this time, patients have no symptoms and physical examination lacks signs of tumor itself, so this stage is called subclinical stage. Once the symptoms of liver cancer appear, most of the patients who come to the clinic have already entered the middle and late stage. In the middle and late stages, the clinical treatment is usually a combination of surgery, radiotherapy and traditional Chinese medicine. The clinical manifestations of different stages of liver cancer are obviously different.  The natural course of liver cancer can be divided into 4 stages: First, early subclinical stage. From the generation of precancerous cells to the establishment of subclinical liver cancer diagnosis, it takes about 10 months, without any symptoms and difficult to be detected by imaging.  Second, subclinical stage. From subclinical hepatocellular carcinoma to the appearance of symptoms, generally about 10 months, often detected by imaging, at this time, if it can be diagnosed early and surgically removed, the 5-year survival rate can reach 60%-70%.  Third, intermediate stage. From the appearance of symptoms to jaundice, ascites or distant metastasis, about 4 months.  Fourth, late stage. That is, from the appearance of jaundice, ascites or distant metastasis to death, about two months. The total course of liver cancer is about two and a half years, of which two years are in the early stage without symptoms, once symptoms appear most patients have only six months of survival time.