The pain of the innermost tooth needs to be examined by a doctor, and according to whether the tooth in pain is a wisdom tooth or not, the tooth will be treated with filling, root canal treatment or local rinsing and medication, or extracted at a later stage. 1. The innermost tooth is not a wisdom tooth: if the patient does not have wisdom teeth and the innermost tooth is the second molar, the patient needs to actively consult a doctor for examination after the emergence of pain, and if the pain is caused by dental caries, filling treatment is needed; if it is caused by endodontitis or periapical periodontitis, root canal treatment is needed. 2. The innermost teeth are wisdom teeth: if the patient has wisdom teeth, the innermost teeth are also wisdom teeth, the pain is mostly caused by wisdom teeth pericoronitis, you need to seek medical treatment for local rinsing, medicine, such as recurrent pain, the need for acute inflammation subsides, selective removal of wisdom teeth, and, if necessary, can be taken under the guidance of the doctor cephalosporin, metronidazole and other anti-inflammatory drugs to assist in the treatment. Toothache needs timely medical examination and treatment, the use of drugs need to comply with medical advice.