Removal of the gallbladder for gallstones may result in dyspepsia, bile reflux, and an increased risk of colorectal cancer, but overall the effects are minor. For symptomatic gallstones, most of them require surgical treatment to remove the gallbladder to avoid progression of the disease and complication of gallbladder cancer. The gallbladder is the organ that stores and concentrates bile, and its removal may have certain effects on the body, as follows: 1. If the bile has substances to promote digestion, which can help fat digestion, the body’s digestive function will be slightly weakened after gallbladder removal, and indigestion, bloating and diarrhea may occur. 2. After gallbladder removal, a large amount of bile can enter the intestines directly, and after accumulation, it can reflux into the stomach, and bile reflux gastritis occurs. 3. Bile that enters the intestine can stimulate intestinal tissues and increase the risk of colorectal cancer. To summarize, although the removal of the gallbladder may cause certain effects, these effects can be minimized by dietary adjustments. When cholecystectomy is a necessary treatment measure, it is recommended to receive treatment as prescribed by the doctor.