Children with a sore throat, especially in the middle of the night, may be acute tonsillitis, acute pharyngitis, acute epiglottitis, etc., the causes are different, the treatment is different, you can use gargle liquid gargle for the cause of the disease, the use of antibiotics, corticosteroids and other drugs. 1. Acute tonsillitis: acute tonsillitis is an acute non-specific inflammatory disease that occurs in the palatine tonsils, the disease can lead to children with sore throats, especially in the middle of the night, serious symptoms, the treatment can be used as a gargle of cotrimoxazole containing excitatory solution. 2. Acute pharyngitis: acute pharyngitis is an acute inflammatory disease that occurs in the pharyngeal mucosa, submucosal tissues and their lymphoid tissues, the disease can lead to children with sore throat, especially in the middle of the night, serious symptoms, the treatment can be used as a gargle of borax, according to the different pathogens, but also the use of ribavirin, amoxicillin, and other medications for treatment. 3. Acute epiglottitis: acute epiglottitis is also known as acute supraglottic laryngitis, the disease can lead to children with sore throats, especially in the middle of the night, serious symptoms, the treatment should try to avoid excessive use of the voice, you can use drugs such as dexamethasone to reduce the laryngeal mucous membrane swelling. In addition to the above diseases, other diseases can also cause sore throat in children, such as mechanical injury of the esophagus, etc. It is recommended to consult a doctor as soon as possible to identify the cause and then carry out targeted treatment. All of the above medications should be used under medical supervision.