Improvement in sensory abnormalities with lipoic acid is related to a number of factors, including the condition, and the time to onset of action varies widely, with some literature suggesting that symptomatic relief is felt after 20 to 180 days of medication. Lipoic acid is primarily used to treat sensory abnormalities caused by diabetic polypoidal peripheral neuropathy. Lipoic acid is metabolized rapidly in the body, reaching the systemic tissues and reaching the maximum blood concentration within 30 minutes, at which time the drug is in effect, but the subjective sensation is usually unchanged. It takes 20 to 180 days of continuous medication to feel relief from neuropathy symptoms such as numbness and pain. Due to the different severity of the disease, the subjective feeling of the onset of the drug may be more different, and the onset of action time is also related to a variety of factors, such as the route of administration, such as oral administration, intravenous administration and so on. The above times are for reference only. The use of this drug is contraindicated in women who are hypersensitive to the components of lipoic acid, nursing or pregnant. Lipoic acid should be used under the supervision of a clinician and unauthorized use is prohibited.