Thyroid nodule is a kind of thyroid disease, thyroid enlargement is a sign of the disease, which can be seen in Hashimoto’s thyroiditis, etc. Thyroid nodule can be manifested as thyroid enlargement. Thyroid enlargement is divided into localized and diffuse enlargement. Localized enlargement of the thyroid gland can be seen in thyroid nodules, thyroid tumors, etc. Diffuse enlargement of the thyroid gland can be seen in Hashimoto’s thyroiditis, Graves’ disease, and subacute thyroiditis. While thyroid nodule is a disease diagnosed by thyroid ultrasound, it is a mass formed by local cell proliferation in the thyroid gland, which can be benign and malignant. Both goiter and thyroid nodule need timely consultation, examination and treatment under doctor’s guidance.