In the comprehensive treatment of diabetes mellitus, although the western medicine approach can control blood glucose more effectively, it still lacks effective measures for the prevention and treatment of diabetic complications. Traditional Chinese medicine has shown good momentum in the field of diabetes prevention and treatment. In recent years, countries in Europe and the United States advocate natural therapies and have shown great interest and enthusiasm in actively searching for natural botanicals that are safe, effective and have no toxic side effects. Chinese medicine has been used to prevent and treat diabetes and its complications for thousands of years, and its efficacy has been confirmed by clinical practice. Chinese medicine integrally regulates, nourishes the five organs, benefits the essence, dispels fatigue and blood, and treats both the symptoms and the root cause, so that the imbalance of yin and yang, disorder of qi and blood, and weakness of internal organs in the body of diabetic patients can be restored and the metabolic disorder of the organism can be corrected. The use of integrated prevention and treatment of Chinese and Western medicine can improve the clinical symptoms of patients, improve the quality of life, and reduce and delay the progressive process of complications. The effectiveness of TCM treatment means that it has certain effect in improving or reducing clinical symptoms and signs (such as typical symptoms of “three more and one less”, fatigue and weakness, etc.), improving patients’ quality of life, and improving relevant experimental indicators (such as fasting blood sugar, postprandial blood sugar, HbA1c, blood lipids, etc.). and the glucose-lowering effect is long-lasting. There are abundant prescriptions of Chinese medicine for the treatment of diabetes, and more than 70 kinds of Chinese medicines and more than 30 compound prescriptions have been confirmed to have hypoglycemic effects. Among the new Chinese medicines, Glucose-lowering A Tablet, which mainly benefits qi and nourishes yin, and Qiringhu Glucose-lowering Tablet (formerly known as Glucose-lowering Tongxin), which activates blood circulation and resolves blood stasis, have good efficacy; Chinese aldose reductase inhibitors and protein non-enzymatic glycation inhibitors have significant advantages over western medicines in preventing and treating diabetic complications. Safety refers to the fact that most of the Chinese herbal medicines for diabetes are natural plants, which usually have fewer side effects and can be taken for a long time. Extensiveness refers to the fact that traditional Chinese medicine not only has the advantages of overall regulation and diagnosis, but also has the characteristics of multi-factor, multi-target, dynamic, combined medication and comprehensive performance of drug effects in treating diabetes. Type II diabetes is an insidious disease, a multifactorial disease, and the emphasis is on comprehensive prevention and treatment, which is in line with the characteristics of Chinese medicine in treating diabetes from overall regulation. Chinese medicine not only has the effect of directly lowering blood glucose, but also has the effect of stopping or delaying the vascular complications of diabetes, which is conducive to the symptom relief of chronic complications and complements and enriches the simple western medicine treatment.