In general, seven days after the circumcision has not changed the medicine, may lead to bacterial infection, or will not occur adverse reactions. 1. Bacterial infection: After circumcision surgery, the wound needs to be changed regularly to keep the wound area clean to reduce the risk of bacterial infection, so seven days after the operation without changing the medicine may lead to local bacterial growth, bacterial infection will lead to redness and swelling of the wound area, pain, and elevated skin temperature and other symptoms, and in serious cases, it will lead to ulceration, pus, and so on. 2. No adverse reactions: For some people with strong body resistance, not changing the medicine for 7 days after circumcision may not lead to bacterial infection. However, it is still recommended to change the medicine regularly to avoid the consequences of bacterial infection. To summarize, the medication should be changed regularly after circumcision and followed up in the hospital.