Demyelinating lesions are usually not completely cured by Chinese medicine, but they should be analyzed specifically according to the patient’s condition, medical history, and physical condition. Demyelinating disease refers to a group of diseases characterized by the loss or thinning of myelin sheaths while the axon is relatively intact. The pathological change in this disease is the loss of the myelin sheath of the nerve fibers, but the nerve cells are relatively intact, so that the function of the transmission of nerve impulses is affected. Demyelination occurs in the central nervous system in the form of multiple sclerosis and in the peripheral nervous system in the form of Guillain-Barre syndrome. The clinical manifestations of demyelinating disease are varied and can be seen as sensory disorders, motor disorders, limb spasms, facial paralysis, vertigo, aphasia, mental disorders and other conditions. Chinese medicine can partially improve the clinical symptoms of demyelinating disease, but it is difficult to completely cure. Demyelinating disease patients should go to a regular hospital, consult a TCM physician for evidence-based guidance, and follow the doctor’s instructions for standardized treatment.