Thyroid nodules are not uncommon in people over middle age. If you find nodular enlargement of the thyroid gland, you should first go to the hospital to check the thyroid function (T3, T4 and TSH) to rule out hyper- or hypothyroidism, and if abnormal function is found, it should be treated promptly. If the thyroid function is normal, the main consideration is whether the nodule is benign or malignant, because malignant nodules must be treated surgically, while benign nodules can be followed up. Therefore, thyroid ultrasound and thyroid nuclear scanning are also done to understand the morphologic changes in the thyroid gland and to determine the shape and size of the thyroid gland and its nodules, so that the nature of the nodules can be initially determined. Although the majority of thyroid nodules are benign, patients with the following symptoms should be alerted to the possibility of thyroid cancer. 1. In non-endemic areas of endemic goiter, a single thyroid nodule in a child under 14 years of age has a very high chance of malignancy, but most are less malignant. 2, Single nodule in the thyroid gland of an adult male. 3, Thyroid nodules that have existed for many years and have increased significantly in size over a short period of time. 4. Patients living in coastal areas have a much higher chance of having a single nodule that is cancerous than patients from endemic goiter areas. 5. A single thyroid nodule is more suspicious in patients who have received radiation therapy to the head and neck during childhood. 6. The nodule is hard, fixed, irregularly shaped, or accompanied by enlarged lymph nodes on the same side of the neck. 7. Hoarseness and dysphagia. 8, Color ultrasound is solid or cystic solid, with uneven internal echoes and unclear borders. 9.Calcified shadow in the thyroid gland is found to be cloudy or granular in neck X-ray. 10.Puncture examination finds tumor cells.