Grade I hypertension may be damaging to the organs. Hypertension is categorized into Grade I, Grade II and Grade III. Grade I hypertension is defined as blood pressure fluctuating between 140-160 mmHg/90-100 mmHg. Sequelae that can result from high blood pressure include: 1. Cerebrovascular disease: when the blood pressure rises, it will impact the blood vessels, and the higher the blood pressure, the greater the impact on the blood vessels leading to deformation of the blood vessels; in the long run, it will make the endothelium of the blood vessels damaged, and the damaged place will form scar-like hyperplasia to make the blood vessel wall thickened, and after the damage of the blood vessel wall, the platelets and other components will pile up on the surface of the damaged tissues, and in the long run, it will form a thrombus, which will result in cerebral infarction and cerebral ischemic attack; when the blood pressure is acutely elevated, the pressure will not be tolerated and progresses to cerebral hemorrhage. 2. Heart failure and coronary heart disease: when blood pressure rises, it causes excessive afterload on the heart, which requires stronger contraction of the heart to pump out blood, and in the long run, it will cause heart failure. 3. Chronic renal failure: when the blood pressure rises, the heart pumps blood with greater difficulty, the amount of circulating blood available to the whole body is less, and the blood supply to the kidneys is reduced, which can cause renal failure. 4. Aortic coarctation: when blood pressure rises, it will cause impact on blood vessels, and it is likely to tear out a new channel, resulting in aortic coarctation. Damage to vital organs such as the heart, kidneys, and brain may occur when first-degree hypertension is poorly controlled with oral medication for a long period of time. If long-term blood pressure control is poor, it is recommended to visit the cardiovascular medicine department of the local hospital and adjust the treatment plan according to the doctor’s guidance.