A nodule in the left adrenal gland requires detailed examination and evaluation in the hospital to decide how to treat it.1 For non-functional adenomas, if the size is <1cm, it is recommended to follow up with clinical observation, and then surgery is recommended if the nodule has increased in size and secretion function, which affects the patient's normal signs and symptoms. If there is no change, clinical observation can be continued.2. For patients with >1cm nodules with secretory function, hospitalization for laparoscopic surgery is recommended. Surgery removes the localized adenoma, removes the endocrine function of the adenoma, and restores the patient’s normal vital signs. For huge left adrenal nodule, even the whole adrenal gland needs to be resected, after which the hormone secretion of the patient needs to be monitored regularly, and hormone replacement therapy needs to be given if necessary.3. If the malignant nodule of the left adrenal gland is examined, early surgical treatment should be carried out, and after the surgery, radiotherapy or chemotherapy should be chosen according to the results of the pathology.