Normal pregnant women are forbidden to use metronidazole drugs, neither oral metronidazole nor metronidazole suppositories to treat vaginal inflammation, so as not to cause abnormal development of the fetus. Metronidazole can be absorbed through the mucous membrane of the vagina, and can reach the placenta through the bloodstream, and enter the fetus through the placental barrier, which will have a certain effect on the fetus. Especially in early pregnancy, just in the fetal organ differentiation period, if the pregnant woman took metronidazole or topical metronidazole suppositories, may cause fetal development abnormalities, and may even cause developmental malformations, so pregnant women in early pregnancy prohibit metronidazole drugs. If a pregnant woman has a systemic disease, such as anaerobic bacteria or inflammation caused by amoebic trichomoniasis, she can be treated accordingly in mid-pregnancy. Diet in early pregnancy needs to be comprehensive and reasonable, do not favor food. Early pregnancy needs to be careful with the use of drugs, so as to avoid the adverse effects of drugs on the embryo. In addition, pregnant women should quit smoking and drinking before pregnancy, so as not to cause intrauterine growth retardation syndrome or lead to fetal malformation.