Locally advanced stage of cardia cancer refers to the latest stage of cancer. Locally advanced stage means that the local tumor invasion is relatively deep and at the same time, there may be outward invasion to the surrounding. Cardia cancer is a relatively common type of gastric cancer, which is in the cardia part of the stomach. In the locally advanced stage of cardia cancer, the degree of infiltration is deeper, and at the same time, it may be accompanied by metastasis of lymph nodes, therefore, surgical treatment cannot be carried out in this period in general. Worsening symptoms of locally advanced stage of cardia cancer include anemia, dehydration or wasting, abdominal mass and liver enlargement, which are easier to be detected as they are accompanied by pain in the process of progression. Locally advanced stage of pancreatic cancer needs timely treatment, and the treatment plan should be determined according to the condition to relieve the patient’s pain.