Kidney cancer nucleus grade III is more serious. Kidney cancer nucleus grade III means that kidney cancer cells are hypodifferentiated or undifferentiated, this type of cancer cells are more malignant, the growth rate of cancer cells is faster, and distant metastasis can easily occur, so the prognosis of kidney cancer nucleus grade III is worse. However, the prognosis of kidney cancer is not serious simply by the nuclear grade III of kidney cancer, but also by the clinical stage of kidney cancer. However, even in the same clinical stage, the prognosis of nuclear grade III kidney cancer is worse than that of grade I and grade II, and the survival period is relatively shorter.